Carnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction?
Laboratory studyOther animals
- Design
- Laboratory study
- What was measured
- Quenching of 4-hydroxy-trans-2,3-nonenal by carnosine, L-histidine, N-acetylcarnosine and beta-alanine in phosphate buffer, reaction product structures, and detection of carnosine-HNE adducts in oxidised rat skeletal muscle homogenate.
What the authors reported
Carnosine was 10 times more active than L-histidine or N-acetylcarnosine as an HNE quencher, and beta-alanine was inactive, indicating the two residues act synergistically with the beta-alanyl group catalysing addition of the imidazole to HNE. Two products in pH-dependent equilibrium were identified: a Michael adduct stabilised as a cyclic hemiacetal and an imine macrocycle. Carnosine-HNE adducts were detected in oxidised rat muscle homogenate.
Limits of this study
Chemical mechanism study. Slug carries a b suffix because another Aldini 2002 paper is in this set; the database already holds an entry named aldini-2002, so check for duplication. Abstract only.
Source
PubMed 12419310 · doi:10.1016/s0006-291x(02)02545-7
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.