Laboratory studies
Studies in cultured cells and laboratory animals. They test how carnosine might work.
A laboratory study shows a mechanism. It does not show an effect in patients. Doses in a dish are often far above the levels measured in human blood. Rats and mice lack the serum enzyme (carnosinase 1) that breaks carnosine down in people, so oral carnosine reaches their tissues in a way it does not in humans. How to read a study page.
169 studies listed, newest first.
- Carnosine decreases PMA-induced oxidative stress and inflammation in murine macrophagesLaboratory studyOther animals
- Evaluation of the transepidermal penetration of a carnosine complex in gel formulation by 3D skin modelsLaboratory studyHumansTopicalWith carnosine-magnesium sulphate complex compared with free carnosine and magnesium alone
- Carnosine concentration in the muscle of thoroughbred horses and its implications in exercise performanceLaboratory studyHorses
- Carnosine inhibits Abeta42 aggregation by perturbing the H-bond network in and around the central hydrophobic clusterLaboratory studyOther animals
- Molecular identification of carnosine N-methyltransferase as chicken histamine N-methyltransferase-like protein (HNMT-like)Laboratory studyOther animals
- Effect of beta-alanine and carnosine supplementation on muscle contractility in miceLaboratory studyOther animalsWith beta-alanine (carnosine precursor) in separate arms
- Beta-alanyl-L-histidine rescues cognitive deficits caused by feeding a high fat diet in a transgenic mouse model of Alzheimer's diseaseLaboratory studyOther animals
- Coupled Ca2+/H+ transport by cytoplasmic buffers regulates local Ca2+ and H+ ion signalingLaboratory studyOther animals
- L-carnosine inhibits neuronal cell apoptosis through signal transducer and activator of transcription 3 signaling pathway after acute focal cerebral ischemiaLaboratory studyOther animals
- Carnosine enhances diabetic wound healing in the db/db mouse model of type 2 diabetesLaboratory studyOther animals
- L-carnosine affects the growth of Saccharomyces cerevisiae in a metabolism-dependent mannerLaboratory studyOther animals
- Effects of carnosine on contractile apparatus Ca2+ sensitivity and sarcoplasmic reticulum Ca2+ release in human skeletal muscle fibersLaboratory studyHumans
- Effect of a zinc L-carnosine compound on acid-induced injury in canine gastric mucosa ex vivoLaboratory studyDogsWith zinc (as a zinc L-carnosine compound)
- Effects of L-carnosine on splenic sympathetic nerve activity and tumor proliferationLaboratory studyOther animals
- Carnosine inhibits KRAS-mediated HCT116 proliferation by affecting ATP and ROS productionLaboratory studyOther animals
- Computational design of effective, bioinspired HOCl antioxidants: the role of intramolecular Cl+ and H+ shiftsLaboratory studyOther animals
- Protective effect of carnosine on subcortical ischemic vascular dementia in miceLaboratory studyOther animals
- The cytotoxic mechanism of malondialdehyde and protective effect of carnosine via protein cross-linking/mitochondrial dysfunction/reactive oxygen species/MAPK pathway in neuronsLaboratory studyOther animals
- Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD miceLaboratory studyOther animals
- Characteristics of oxidative stress in experimental rat brain ischemia aggravated by homocysteic acidLaboratory studyOther animals
- Protection against adriamycin-induced cardiomyopathy by carnosine in rats: role of endogenous antioxidantsLaboratory studyOther animals
- L-carnosine inhibits high-glucose-mediated matrix accumulation in human mesangial cells by interfering with TGF-beta production and signallingLaboratory studyOther animals
- Mass spectrometry assay for studying kinetic properties of dipeptidases: characterization of human and yeast dipeptidasesLaboratory studyHumansOther animals
- Determination of carnosine, anserine, homocarnosine, pentosidine and thiobarbituric acid reactive substances contents in meat from different animal speciesLaboratory studyHorsesOther animals
- Oral carnosine supplementation prevents vascular damage in experimental diabetic retinopathyLaboratory studyOther animals
- Carnosine prevents apoptosis of glomerular cells and podocyte loss in STZ diabetic ratsLaboratory studyOther animals
- Carnosine pretreatment protects against hypoxia-ischemia brain damage in the neonatal rat modelLaboratory studyOther animals
- The effect of carnosine pretreatment on oxidative stress and hepatotoxicity in binge ethanol administered ratsLaboratory studyOther animals
- The effect of carnosine treatment on prooxidant-antioxidant balance in liver, heart and brain tissues of male aged ratsLaboratory studyOther animals
- Effect of carnosine against thioacetamide-induced liver cirrhosis in ratLaboratory studyOther animals
- Carnosine inhibits degradation of hyaluronan induced by free radical processes in vitro and improves the redox imbalance in adjuvant arthritis in vivoLaboratory studyOther animals
- Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1)Laboratory studyOther animals
- Ginger extract and polaprezinc exert gastroprotective actions by anti-oxidant and growth factor modulating effects in ratsLaboratory studyOther animalsWith zinc (as polaprezinc); ginger extract tested in parallel
- Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in ratsLaboratory studyOther animals
- Carnosine supplementation protects rat brain tissue against ethanol-induced oxidative stressLaboratory studyOther animals
- Relevance of allosteric conformations and homocarnosine concentration on carnosinase activityLaboratory studyHumans
- N-Glycosylation of Carnosinase Influences Protein Secretion and Enzyme Activity: Implications for HyperglycemiaLaboratory studyHumansOther animals
- Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knockout mice by reducing glutamate excitotoxicityLaboratory studyOther animals
- Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract diseaseLaboratory studyOther animals
- Inhibitory effect of carnosine and N-acetyl carnosine on LPS-induced microglial oxidative stress and inflammationLaboratory studyOther animals
- Transport mechanisms of carnosine in SKPT cells: contribution of apical and basolateral membrane transportersLaboratory studyOther animals
- Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null miceLaboratory studyOther animals
- Effects of L-carnosine in preventing and treating rat cataract induced by sodium seleniteLaboratory studyOther animalsTopical
- Carnosine facilitates nitric oxide production in endothelial F-2 cellsLaboratory studyOther animals
- Protective effects from carnosine and histidine on acetaminophen-induced liver injuryLaboratory studyOther animalsWith histidine tested in separate arms
- Creatine supplementation augments skeletal muscle carnosine content in senescence-accelerated mice (SAMP8)Laboratory studyOther animals
- Protective effect of carnosine against cisplatin-induced nephrotoxicity in miceLaboratory studyOther animals
- Carnosine protects against Abeta42-induced neurotoxicity in differentiated rat PC12 cellsLaboratory studyOther animals
- Effects of dietary carnosine and vitamin E on antioxidant and oxidative status of ratsLaboratory studyOther animalsWith vitamin E (in some groups)
- Beneficial effects of histidine and carnosine on ethanol-induced chronic liver injuryLaboratory studyOther animalsWith histidine (tested in parallel arms)
- Safety evaluation of chicken breast extract containing carnosine and anserineLaboratory studyOther animalsWith anserine (chicken breast extract containing carnosine and anserine)
- Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2Laboratory studyOther animals
- Antiglycation and antioxidant effect of carnosine against glucose degradation products in peritoneal mesothelial cellsLaboratory studyOther animals
- Carnosine concentration of ingested meat affects carnosine net release into the portal vein of minipigsLaboratory studyOther animals
- Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processesLaboratory studyOther animalsHumansWith zinc (as zinc carnosine)
- Carnosine interaction with nitric oxide and astroglial cell protectionLaboratory studyOther animals
- HNE Michael adducts to histidine and histidine-containing peptides as biomarkers of lipid-derived carbonyl stress in urines: LC-MS/MS profiling in Zucker obese ratsLaboratory studyOther animals
- Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitroLaboratory studyOther animals
- A CTG Polymorphism in the CNDP1 Gene Determines the Secretion of Serum Carnosinase in Cos-7-Transfected CellsLaboratory studyHumansOther animals
- Oral administration of chicken breast extract increases brain carnosine and anserine concentrations in ratsLaboratory studyOther animalsWith anserine (as chicken breast extract)
- Purification and characterization of a novel imidazole dipeptide synthase from the muscle of the Japanese eel Anguilla japonicaLaboratory studyOther animals
- Renoprotective effects of l-carnosine on ischemia/reperfusion-induced renal injury in ratsLaboratory studyOther animals
- Evidence for rapid inter- and intramolecular chlorine transfer reactions of histamine and carnosine chloramines: implications for the prevention of hypochlorous-acid-mediated damageLaboratory studyOther animals
- PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytesLaboratory studyOther animals
- Amyloid-beta induced cell death is independent of free radicalsLaboratory studyOther animals
- Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycationLaboratory studyOther animalsWith histidine (tested in parallel arms)
- LC-ESI-MS/MS determination of 4-hydroxy-trans-2-nonenal Michael adducts with cysteine and histidine-containing peptides as early markers of oxidative stress in excitable tissuesLaboratory studyOther animals
- Carnosine and anserine act as effective transglycating agents in decomposition of aldose-derived Schiff basesLaboratory studyOther animals
- Nitric oxide involves in carnosine-induced hyperactivity in chicksLaboratory studyOther animals
- Carnosine protects against the inactivation of esterase induced by glycation and a steroidLaboratory studyOther animals
- Profiling histidine-containing dipeptides in rat tissues by liquid chromatography/electrospray ionization tandem mass spectrometryLaboratory studyOther animals
- Effect of carnosine on excitation-contraction coupling in mechanically-skinned rat skeletal muscleLaboratory studyOther animals
- Anti-crosslinking properties of carnosine: significance of histidineLaboratory studyOther animals
- Gender-related differences in carnosine, anserine and lysine content of murine skeletal muscleLaboratory studyOther animals
- Carnosine disaggregates glycated alpha-crystallin: an in vitro studyLaboratory studyOther animals
- Carnosine uptake in rat choroid plexus primary cell cultures and choroid plexus whole tissue from PEPT2 null miceLaboratory studyOther animals
- Acrolein-sequestering ability of endogenous dipeptides: characterization of carnosine and homocarnosine/acrolein adducts by electrospray ionization tandem mass spectrometryLaboratory studyOther animals
- Preventive effect of L-carnosine on ischemia/reperfusion-induced acute renal failure in ratsLaboratory studyOther animals
- Enhanced oligomerization of the alpha-synuclein mutant by the Cu,Zn-superoxide dismutase and hydrogen peroxide systemLaboratory studyOther animals
- Carnosine inhibits (E)-4-hydroxy-2-nonenal-induced protein cross-linking: structural characterization of carnosine-HNE adductsLaboratory studyOther animals
- Sequence Identification and Characterization of Human Carnosinase and a Closely Related Non-specific DipeptidaseLaboratory studyOther animals
- Carnosine promotes the heat denaturation of glycated proteinLaboratory studyOther animals
- Carnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction?Laboratory studyOther animals
- Detoxification of cytotoxic alpha,beta-unsaturated aldehydes by carnosine: characterization of conjugated adducts by electrospray ionization tandem mass spectrometry and detection by liquid chromatography/mass spectrometry in rat skeletal muscleLaboratory studyOther animals
- l-carnosine and verapamil inhibit hypoxia-induced expression of hypoxia inducible factor (HIF-1 alpha) in H9c2 cardiomyoblastsLaboratory studyOther animals
- Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudodipeptidesLaboratory studyOther animals
- Inhibitory effect of polaprezinc on the inflammatory response to Helicobacter pyloriLaboratory studyOther animalsWith zinc (as polaprezinc)
- Protective effects of carnosine, homocarnosine and anserine against peroxyl radical-mediated Cu,Zn-superoxide dismutase modificationLaboratory studyOther animals
- The ceruloplasmin and hydrogen peroxide system induces alpha-synuclein aggregation in vitroLaboratory studyOther animals
- Effects of L-carnosine on renal sympathetic nerve activity and DOCA-salt hypertension in ratsLaboratory studyOther animals
- The natural substrate for nitric oxide synthase activityLaboratory studyOther animals
- In vitro and in vivo inhibition of muscle lipid and protein oxidation by carnosineLaboratory studyOther animalsWith histidine-supplemented diet (used in vivo to raise muscle carnosine)
- Carnosine reacts with a glycated proteinLaboratory studyOther animals
- A re-evaluation of the antioxidant activity of purified carnosineLaboratory studyOther animals
- Endogenous mechanisms of neuroprotection: role of zinc, copper, and carnosineLaboratory studyOther animals
- Polaprezinc exerts a salutary effect on impaired healing of acute gastric lesions in diabetic ratsLaboratory studyOther animalsWith zinc (as polaprezinc)
- Hydrolysis of carnosine and related compounds by mammalian carnosinasesLaboratory studyHumansOther animals
- Vasodilatory actions of the dietary peptide carnosineLaboratory studyOther animals
- Carnosine prevents the glycation-induced changes in electrophoretic mobility of aspartate aminotransferaseLaboratory studyOther animals
- Carnosine as a regulator of soluble guanylate cyclaseLaboratory studyOther animals
- Binding of copper(II) to carnosine: Raman and IR spectroscopic studyLaboratory studyOther animals
- Raman and IR spectroscopic investigation of zinc(II)-carnosine complexesLaboratory studyOther animalsWith zinc (zinc(II)-carnosine complexes)
- Hydrogen peroxide-mediated Cu,Zn-superoxide dismutase fragmentation: protection by carnosine, homocarnosine and anserineLaboratory studyOther animals
- Further evidence for the rejuvenating effects of the dipeptide L-carnosine on cultured human diploid fibroblastsLaboratory studyOther animals
- Ulcerogenic and healing impairing actions of monochloramine in rat stomachs: effects of zinc L-carnosine, polaprezincLaboratory studyOther animalsWith zinc (as polaprezinc)
- Effect of polaprezinc (N-(3-aminopropionyl)-L-histidinato zinc), a novel antiulcer agent containing zinc, on cellular proliferation: role of insulin-like growth factor ILaboratory studyOther animalsWith zinc (as polaprezinc)
- Hydroxyl radical scavenging by carnosine and Cu(II)-carnosine complexes: a pulse-radiolysis and spectroscopic studyLaboratory studyOther animals
- Effect of carnosine on age-induced changes in senescence-accelerated miceLaboratory studyOther animals
- Ability of carnosine and other skeletal muscle components to quench unsaturated aldehydic lipid oxidation productsLaboratory studyOther animals
- Carnosine and beta-alanine release is stimulated by glutamatergic receptors in cultured rat oligodendrocytesLaboratory studyOther animals
- Carnosine and taurine contents in individual fibres of human vastus lateralis muscleLaboratory studyHumans
- Analysis of an H1 receptor-mediated, zinc-potentiated vasoconstrictor action of the histidyl dipeptide carnosine in rabbit saphenous veinLaboratory studyOther animals
- Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine and beta-alanineLaboratory studyOther animals
- A pulse radiolysis study of carnosine in aqueous solutionLaboratory studyOther animals
- Carnosine modulates zinc and copper effects on amino acid receptors and synaptic transmissionLaboratory studyOther animals
- Insulin-like growth factor I plays a role in gastric wound healing: evidence using a zinc derivative, polaprezinc, and an in vitro rabbit wound repair modelLaboratory studyOther animalsWith zinc (as polaprezinc)
- Identification of hydrazine in commercial preparations of carnosine and its influence on carnosine's antioxidative propertiesLaboratory studyOther animals
- Histidine-containing dipeptides as endogenous regulators of the activity of sarcoplasmic reticulum Ca-release channelsLaboratory studyOther animals
- High-performance liquid chromatographic determination of imidazole dipeptides, histidine, 1-methylhistidine and 3-methylhistidine in equine and camel muscle and individual muscle fibresLaboratory studyHorsesOther animals
- High-performance liquid chromatographic determination of N-alpha-acetyl-L-carnosine in equine plasmaLaboratory studyHorses
- Quenching of singlet molecular oxygen by carnosine and related antioxidants. Monitoring 1270-nm phosphorescence in aqueous mediaLaboratory studyOther animals
- Evidence for a direct interaction of superoxide anion radical with carnosineLaboratory studyOther animals
- Co-localization of carnosine and glutamate in photoreceptors and bipolar cells of the frog retinaLaboratory studyOther animals
- Carnosine is a novel peptide modulator of intracellular calcium and contractility in cardiac cellsLaboratory studyOther animals
- Calcium-sensitizing function for the dipeptide carnosine in skeletal muscle contractilityLaboratory studyOther animals
- N alpha-acetylcarnosine is a prodrug of L-carnosine in ophthalmic application as antioxidantLaboratory studyOther animalsTopicalWith N-acetylcarnosine (carnosine prodrug)
- Carnosine-synthesis in cultures of rat glial cells is restricted to oligodendrocytes and carnosine uptake to astrocytesLaboratory studyOther animals
- Inhibition of the growth of transformed and neoplastic cells by the dipeptide carnosineLaboratory studyOther animals
- The dipeptide carnosine constricts rabbit saphenous vein as a zinc complex apparently via a serotonergic receptorLaboratory studyOther animalsWith zinc (as zinc-carnosine complex)
- Residence time of polaprezinc (zinc L-carnosine complex) in the rat stomach and adhesiveness to ulcerous sitesLaboratory studyOther animalsWith zinc (as polaprezinc)
- Non-enzymatic glycosylation of the dipeptide L-carnosine, a potential anti-protein-cross-linking agentLaboratory studyOther animals
- Biosynthesis of carnosine and related peptides by skeletal muscle cells in primary cultureLaboratory studyOther animals
- Cellular localization of carnosinase in the human nasal mucosaLaboratory studyHumans
- Retardation of the senescence of cultured human diploid fibroblasts by carnosineLaboratory studyOther animals
- The mechanism of interaction of carnosine with superoxide radicals in water solutionsLaboratory studyOther animals
- Presynaptic co-localization of carnosine and glutamate in olfactory neuronesLaboratory studyOther animals
- Determination of carnosine and other biogenic imidazoles in equine plasma by isocratic reversed-phase ion-pair high-performance liquid chromatographyLaboratory studyHorsesDogsHumans
- Histidine dipeptide levels in ageing and hypertensive rat skeletal and cardiac musclesLaboratory studyOther animals
- Calcium sensitizing action of carnosine and other endogenous imidazoles in chemically skinned striated muscleLaboratory studyOther animals
- Analysis of novel imidazoles from isolated perfused rabbit heart by two high-performance liquid chromatographic methodsLaboratory studyOther animals
- Major buffering constituents in animal muscleLaboratory studyOther animals
- Intestinal absorption of the intact peptide carnosine in man, and comparison with intestinal permeability to lactuloseLaboratory studyHumans
- Purification and properties of human serum carnosinaseLaboratory studyHumansOther animals
- Cellular localization of carnosine-like and anserine-like immunoreactivities in rodent and avian central nervous systemLaboratory studyOther animals
- Scavenging of singlet molecular oxygen by imidazole compounds: high and sustained activities of carboxy terminal histidine dipeptides and exceptional activity of imidazole-4-acetic acidLaboratory studyOther animals
- Separation and characterization of two carnosine-splitting cytosolic dipeptidases from hog kidney (carnosinase and non-specific dipeptidase)Laboratory studyOther animals
- Antioxidant activity of L-carnosine, a natural histidine-containing dipeptide in crystalline lensLaboratory studyOther animals
- A comparative study of synthetic carnosine analogs as antioxidantsLaboratory studyOther animals
- Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brainLaboratory studyOther animals
- Detection, characterisation, and quantification of carnosine and other histidyl derivatives in cardiac and skeletal muscleLaboratory studyOther animals
- Intracellular pH in human skeletal muscle by 1H NMRLaboratory studyHumans
- The antioxidative properties of carnosine, a natural histidine containing dipeptideLaboratory studyDogsOther animals
- Monoclonal antibodies to mammalian carnosine synthetaseLaboratory studyOther animals
- Role of histidine-related compounds to intracellular buffering in fish skeletal muscleLaboratory studyOther animals
- Enhanced carnosine (beta-alanyl-L-histidine) breakdown and histamine metabolism following treatment with compound 48/80Laboratory studyOther animals
- Homocarnosinosis: lack of serum carnosinase is the defect probably responsible for elevated brain and CSF homocarnosineLaboratory studyHumans
- Biosynthesis of carnosine and related peptides by glial cells in primary cultureLaboratory studyOther animals
- Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmiumLaboratory studyHumans
- Regional distribution of homocarnosine, homocarnosine-carnosine synthetase and homocarnosinase in human brainLaboratory studyHumans
- Purification and characterization of carnosine synthetase from mouse olfactory bulbsLaboratory studyOther animals
- Regional and subcellular distribution of homocarnosine-carnosine synthetase in the central nervous system of ratsLaboratory studyOther animals
- Denervation in the primary olfactory pathway of mice. IV. Biochemical and morphological evidence for neuronal replacement following nerve sectionLaboratory studyOther animals
- Effect of histidine-free and -excess diets on anserine and carnosine contents in rat gastrocnemius muscleLaboratory studyOther animalsWith dietary histidine (carnosine precursor), not carnosine itself
- Denervation in the primary olfactory pathway of mice. III. Effect on enzymes of carnosine metabolismLaboratory studyOther animals
- Carnosinase activity of human gastrointestinal mucosaLaboratory studyHumansOther animals
- Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of valuesLaboratory studyHumans
- Carnosine in the primary olfactory pathwayLaboratory studyOther animals
- Some properties of a homocarnosine-carnosine synthetase isolated from rat brainLaboratory studyOther animals
- Ueber das Carnosin, eine neue organische Base des Fleischextractes (On carnosine, a new organic base of meat extract)Laboratory studyOther animals