Biosynthesis of carnosine and related peptides by glial cells in primary culture

Bauer K, Hallermayer K, Salnikow J, et al.. Journal of Biological Chemistry, 1982; 257(7):3593-3597.

Laboratory studyOther animals

Design

Laboratory study

What was measured

Incorporation of [3H]beta-alanine and GABA into carnosine, homocarnosine and related dipeptides by primary glial cultures, with and without aminooxyacetic acid.

What the authors reported

Glial cells synthesised carnosine and related peptides from labelled beta-alanine. Labelled GABA was rapidly degraded with little homocarnosine formed; aminooxyacetic acid blocked GABA degradation and enabled homocarnosine synthesis, showing glia can make both dipeptides.

Limits of this study

Cell culture. Full text not read.

Source

PubMed 7061500 · doi:10.1016/S0021-9258(18)34821-X

Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.