Amyloid-beta induced cell death is independent of free radicals
Laboratory studyOther animals
- Design
- Laboratory study
- What was measured
- Viability, intracellular calcium and reactive oxygen species in rat cerebellar granule neurons exposed to amyloid-beta (1-42), by flow cytometry, with and without carnosine.
What the authors reported
Amyloid-beta caused dose-dependent loss of viability without a significant rise in calcium or reactive oxygen species. Carnosine partially reduced the cell death. The authors conclude the death was not driven by calcium or ROS.
Limits of this study
Acutely dissociated cells; doses not stated in abstract. Full text not read.
Source
PubMed 15665403 · doi:10.3233/jad-2004-6607
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.