Acrolein-sequestering ability of endogenous dipeptides: characterization of carnosine and homocarnosine/acrolein adducts by electrospray ionization tandem mass spectrometry
Laboratory studyOther animals
- Design
- Laboratory study
- What was measured
- Quenching of acrolein by carnosine and homocarnosine in phosphate buffer; adduct structures by ESI-MS/MS.
What the authors reported
Both dipeptides quenched about 60% of acrolein at 1 h and more than 85% after 3 h. Several adduct products were identified, indicating a complex reaction pathway. The authors frame this as relevant to acrolein elevation in Alzheimer's disease brain.
Limits of this study
In vitro chemistry only. Full text not read.
Source
PubMed 14505328 · doi:10.1002/jms.517
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.