Double-Blind, Placebo-Controlled Study of L-Carnosine Supplementation in Children With Autistic Spectrum Disorders
Randomised controlled trialHumans
- Design
- Randomised controlled trial
- Subjects
- 31 children with autism spectrum disorders
- Dose used in the study
- 800 mg carnosine per day
- Duration
- 8 weeks
- What was measured
- Childhood Autism Rating Scale, Gilliam Autism Rating Scale, Expressive and Receptive One-Word Picture Vocabulary Tests, Clinical Global Impressions of Change.
What the authors reported
The placebo group showed no statistically significant changes. After 8 weeks the carnosine group improved on the Gilliam total score and its behaviour, socialisation and communication subscales, and on the Receptive One-Word Picture Vocabulary Test (all p < 0.05). Other measures showed trends. The authors said the mechanism is not well understood.
Limits of this study
Small trial (31 children). Eight weeks. Group sizes not given in the abstract. Older study not replicated at scale. Full text not read.
Source
PubMed 12585724 · doi:10.1177/08830738020170111501
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.