Creatine supplementation augments skeletal muscle carnosine content in senescence-accelerated mice (SAMP8)
Laboratory studyOther animals
- Design
- Laboratory study
- Dose used in the study
- Creatine at 2 percent of food intake
- Duration
- 10 to 60 weeks of age
- What was measured
- Muscle carnosine, anserine, taurine and total creatine in tibialis anterior, and in vitro contractile fatigue and recovery of soleus and EDL muscles, in male SAMP8 mice fed control or creatine-supplemented diets.
What the authors reported
From 10 to 60 weeks of age, muscle carnosine fell 45 percent, taurine 24 percent and total creatine 42 percent. At 25 weeks, creatine feeding raised carnosine by 88 percent and anserine by 40 percent versus controls; this effect was absent at 60 weeks, and taurine and total creatine were not affected at any age. At 25 weeks, creatine-treated mice also showed less soleus fatigue and better EDL force recovery, but not at 60 weeks.
Limits of this study
Mouse model, creatine not carnosine was fed; sample size not stated in abstract. Full text not read.
Source
PubMed 18593282 · doi:10.1089/rej.2008.0699
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.