Inhibitory effect of carnosine and N-acetyl carnosine on LPS-induced microglial oxidative stress and inflammation
Laboratory studyOther animals
- Design
- Laboratory study
- What was measured
- Nitric oxide synthesis, inducible nitric oxide synthase expression, TNF-alpha secretion and carbonyl formation in LPS-stimulated BV2 microglial cells treated with carnosine or N-acetylcarnosine; direct interaction of N-acetylcarnosine with nitric oxide by spectrophotometry and mass spectrometry.
What the authors reported
Carnosine and N-acetylcarnosine reduced LPS-induced nitric oxide synthesis and iNOS expression by 60 and 70 percent respectively, and both reduced TNF-alpha secretion and carbonyl formation. N-acetylcarnosine was more potent than carnosine and was shown to interact directly with nitric oxide.
Limits of this study
Microglial cell line; concentrations not stated in abstract. Abstract only.
Source
PubMed 19540429 · doi:10.1016/j.peptides.2009.04.003
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.