Carnosine reacts with protein carbonyl groups: another possible role for the anti-ageing peptide?
ReviewOther animals
- Design
- Review
- What was measured
- Hypothesis paper on carnosine's reaction with carbonyl groups on oxidised or glycated proteins (carnosinylation) and the possible fates of the modified proteins.
What the authors reported
The authors propose that, beyond its antioxidant and radical-scavenging actions, carnosine may take part directly in inactivating and disposing of aged proteins by reacting with their carbonyl groups. Possible fates of carnosinylated proteins include formation of inert lipofuscin, proteasomal proteolysis and receptor-mediated exocytosis.
Limits of this study
Hypothesis article; no new experimental data in the abstract. Abstract only.
Source
PubMed 11707898 · doi:10.1023/a:1010057412184
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.