Carnosine inhibits KRAS-mediated HCT116 proliferation by affecting ATP and ROS production

Iovine B, Iannella ML, Nocella F, et al.. Cancer Letters, 2012; 315(2):122-128.

Laboratory studyOther animals

Design

Laboratory study

Dose used in the study

50 to 100 mM carnosine in culture

What was measured

Proliferation, ATP and ROS concentration, cell cycle distribution, ERK1/2 phosphorylation and p21waf1 protein in HCT116 human colon cancer cells carrying an activating KRAS mutation.

What the authors reported

Carnosine at 50 to 100 mM decreased ATP and ROS, induced G1 cell cycle arrest, reduced ERK1/2 phosphorylation and increased p21waf1. The authors conclude carnosine inhibits HCT116 growth through antioxidant action and effects on glycolysis.

Limits of this study

Single cell line at very high concentrations. Abstract only.

Source

PubMed 22137144 · doi:10.1016/j.canlet.2011.07.021

Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.