Calcium sensitizing action of carnosine and other endogenous imidazoles in chemically skinned striated muscle
Laboratory studyOther animals
- Design
- Laboratory study
- Dose used in the study
- Millimolar concentrations, described as near physiological for many skeletal fibres; concentration-dependent
- What was measured
- Calcium-tension relationship and maximal calcium-activated force in saponin or Triton X-100 skinned frog and crab skeletal muscle and rat cardiac preparations, with carnosine, homocarnosine and N-acetyl-L-histidine.
What the authors reported
Carnosine shifted the calcium-tension curve to lower calcium concentrations in a concentration-dependent way in frog skeletal and rat cardiac muscle but not in crab muscle. Homocarnosine was somewhat more effective in heart, and N-acetyl-L-histidine much less so. Maximal calcium-activated force was increased significantly by homocarnosine in cardiac trabeculae. The authors propose these imidazoles act as natural calcium sensitisers in striated muscle.
Limits of this study
Skinned fibre preparations; n not stated in abstract. Full text not read.
Source
PubMed 1474497 · doi:10.1113/jphysiol.1992.sp019271
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.