Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium
Laboratory studyHumans
- Design
- Laboratory study
- What was measured
- Serum carnosinase activity by a fluorometric assay, activation by cadmium and manganese, substrate range and molecular weight compared with cellular carnosinase, number of molecular forms, and variation with age.
What the authors reported
Average adult serum hydrolysed 42 micromol carnosine per mL per hour, about 17 times earlier literature values; cadmium was twice as effective as manganese as an activator. Serum carnosinase (Mr about 160,000) hydrolysed homocarnosine whereas the cellular isozyme (Mr about 90,000) did not, and only one serum form was detected. Activity varied greatly between individuals, was absent or minimal below 10 months of age and rose gradually to the adult range at 13 to 15 years.
Limits of this study
Biochemical characterisation; sample sizes not stated in abstract. Abstract only.
Source
PubMed 7116644 · doi:10.1016/0009-8981(82)90166-8
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.