Further evidence for the rejuvenating effects of the dipeptide L-carnosine on cultured human diploid fibroblasts
Laboratory studyOther animals
- Design
- Laboratory study
- Dose used in the study
- 50 mM carnosine in culture medium
- What was measured
- Morphology, lifespan in population doublings, cell attachment, plating efficiency and long-term substrate attachment of MRC-5 and HFF-1 human fibroblasts with and without carnosine.
What the authors reported
Late-passage HFF-1 cells kept a juvenile appearance in 50 mM carnosine and reverted to a senescent phenotype when it was removed; switching medium switched the phenotype in both directions. Carnosine did not affect cell attachment but increased longevity in population doublings and strongly increased plating efficiency of young and senescent MRC-5 cells at low density. Very late-passage cells stayed attached longer and looked more normal in carnosine.
Limits of this study
Cell culture at 50 mM, far above physiological plasma levels. Abstract only.
Source
PubMed 10197726 · doi:10.1016/s0531-5565(98)00056-4
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.