Role of L-carnosine in the control of blood glucose, blood pressure, thermogenesis, and lipolysis by autonomic nerves in rats: involvement of the circadian clock and histamine
ReviewOther animals
- Design
- Review
- What was measured
- Review of rat studies on carnosine's effects on sympathetic and parasympathetic nerves to adrenal glands, liver, kidney, pancreas, stomach and adipose tissue, and on blood pressure, glucose, appetite, lipolysis and thermogenesis.
What the authors reported
Carnosine altered autonomic nerve activity and the associated physiological functions; these effects were abolished by histamine H1 or H3 antagonists and by lesions of the suprachiasmatic nucleus. Carnosinase 2 was localised to histamine neurons in the tuberomammillary nucleus, leading to the proposal that carnosine released from muscle is hydrolysed in these neurons to histidine and converted to histamine, mediating hypoglycaemic, hypotensive and lipolytic actions.
Limits of this study
Narrative review of rodent work; corresponding author at a commercial research company (ANBAS). Abstract only.
Source
PubMed 22367578 · doi:10.1007/s00726-012-1251-9
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.