Intracellular pH in human skeletal muscle by 1H NMR

Pan JW, Hamm JR, Rothman DL, et al.. Proceedings of the National Academy of Sciences of the USA, 1988; 85(21):7836-7839.

Laboratory studyHumans

Design

Laboratory study

What was measured

Chemical shifts of the C-2 and C-4 imidazole protons of carnosine in living human skeletal muscle at 4.7 T, used as an intracellular pH probe at rest and during recovery from exhaustive exercise.

What the authors reported

Carnosine imidazole resonances were observed in vivo and gave resting muscle pH of 7.01 +/- 0.04 (C-2 proton) and 6.97 +/- 0.10 (C-4 proton). After exhaustive exercise, during which muscle pH recovers from an acidic value of 6.1, pH from the carnosine C-2 resonance agreed closely with pH from inorganic phosphate on 31P NMR.

Limits of this study

Methods paper; small number of subjects not stated in abstract. Full text not read.

Source

PubMed 3186694 · doi:10.1073/pnas.85.21.7836

Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.