Carnosine is neuroprotective against permanent focal cerebral ischemia in mice
Controlled trialOther animals
- Design
- Controlled trial
- Subjects
- not stated in abstract (mice)
- Dose used in the study
- not stated in abstract
- Duration
- not stated in abstract (carnosine given before and after ischaemia)
- What was measured
- Infarct size, neuronal damage, reactive oxygen species, glutathione, and matrix metalloproteinase protein levels and activity in a mouse model of permanent focal cerebral ischaemia.
What the authors reported
The authors report that carnosine significantly reduced infarct size and neuronal damage when given before and after the onset of ischaemia. It lowered reactive oxygen species in the ischaemic brain, preserved glutathione levels, and decreased matrix metalloproteinase protein and activity. They conclude that carnosine is neuroprotective in focal cerebral ischaemia and appears to counter processes activated after ischaemia begins.
Limits of this study
Mouse model; dose, route timing and group sizes are not given in the abstract. Route recorded as 'other' because injection is the usual route in this model, but the abstract does not state it. Full text not read.
Source
PubMed 17916766 · doi:10.1161/STROKEAHA.107.488502
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.