Nitric oxide involves in carnosine-induced hyperactivity in chicks
Laboratory studyOther animals
- Design
- Laboratory study
- Dose used in the study
- 3.2 micromol carnosine intracerebroventricularly
- What was measured
- Locomotor hyperactivity in chicks after intracerebroventricular carnosine, co-administered with a non-selective NOS inhibitor (L-NAME), its inactive isomer or a selective iNOS inhibitor.
What the authors reported
Carnosine-induced hyperactivity was attenuated dose-dependently by L-NAME (200 and 400 nmol) but not by the inactive D-isomer or by a selective iNOS inhibitor. The authors conclude the behavioural effect is linked to constitutive nitric oxide synthase.
Limits of this study
Chick model with central injection. Abstract only.
Source
PubMed 16236277 · doi:10.1016/j.ejphar.2005.09.008
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.