Carnosine modulates zinc and copper effects on amino acid receptors and synaptic transmission
Laboratory studyOther animals
- Design
- Laboratory study
- What was measured
- Whole-cell voltage-clamp currents in cultured rat olfactory bulb neurons in response to glutamate, GABA and glycine, with zinc, copper and carnosine.
What the authors reported
Carnosine alone evoked no membrane current and did not affect currents evoked by glutamate, GABA or glycine. Copper and zinc inhibited NMDA and GABA receptor-mediated currents and inhibited synaptic transmission. Carnosine prevented the actions of copper and reduced the effects of zinc. The authors suggest carnosine may indirectly influence neuronal excitability by modulating zinc and copper effects.
Limits of this study
Cell culture; concentrations not stated in abstract. Full text not read.
Source
PubMed 9855307 · doi:10.1097/00001756-199810260-00031
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.