Antioxidative and Anti-Inflammatory Protection from Carnosine in the Striatum of MPTP-Treated Mice
Controlled trialOther animals
- Design
- Controlled trial
- Dose used in the study
- 0.5, 1 or 2 g/L carnosine in drinking water
- Duration
- 4 weeks
- What was measured
- Striatal glutathione, antioxidant enzymes, oxidative markers, cytokines, nitrite, iNOS, dopamine and metabolites in MPTP-treated mice.
What the authors reported
MPTP depleted striatal glutathione, lowered glutathione peroxidase, superoxide dismutase and catalase, and raised malondialdehyde, reactive oxygen species, interleukin-6, TNF-alpha, nitrite and iNOS activity (P < 0.05). Carnosine given in drinking water before MPTP attenuated these changes, raised GPX mRNA and lowered iNOS mRNA, improved MPTP-induced dopamine depletion and maintained DOPAC and homovanillic acid levels (P < 0.05). The authors suggest carnosine could provide antioxidative and anti-inflammatory protection for the striatum.
Limits of this study
Group sizes not stated in abstract. Rodents lack serum carnosinase, so oral results do not carry over to people. Full text not read.
Source
PubMed 20925384 · doi:10.1021/jf103258p
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.