Other countries

United States

• L-carnosine is sold as a dietary supplement. No new dietary ingredient notification or GRAS notice for plain L-carnosine was found. Whether it is treated as a pre-1994 ingredient is not stated by a source this site could check.
• Zinc-L-carnosine (PepZin GI): the FDA allowed its sale in 2002 after a new dietary ingredient submission (FoodNavigator 2002).
• Beta-alanine: the FDA acknowledged without objection a new dietary ingredient notification for CarnoSyn beta-alanine at 6.4 g a day in 2019 (BioSpace 2019).
• N-acetylcarnosine eye drops are marketed as a supplement, not a drug.

European Union

• Health claims: EFSA assessed claims for L-carnosine in 2011, for muscle power, endurance, skin and heart function (EFSA Journal 2011). No carnosine claim appears in the authorised list, Commission Regulation (EU) 432/2012 (EUR-Lex), which is consistent with the claims not being accepted.
• Zinc-L-carnosine as a novel food: EFSA’s 2022 opinion concluded the substance is absorbed and supplies zinc, but that its safety “has not been established” because it was insufficiently characterised (EFSA Journal 2022). Whether it has since been added to the Union list was not confirmed.
• Novel food status of plain L-carnosine: not confirmed by this site.

Japan

Polaprezinc (Promac, Zeria) is an approved medicine for gastric ulcer, in the Japanese Pharmacopoeia, with an NHI price listing since 1994 (PMDA interview form; KEGG D01611). It is also approved in South Korea and China.

Checked 11 October 2026.