Gut

Published human trials in the stomach and gut. Nearly all tested zinc-L-carnosine (polaprezinc), a zinc complex of carnosine, in gastric ulcer, Helicobacter pylori therapy, oral mucositis and gut permeability.

This page lists published studies. It reports what the authors did and found, with the limits of each study. It is not advice.

10 studies listed, newest first.

• Protective and Healing Effects of Zinc L-Carnosine on the Oral Mucosa: A Systematic Review and Meta-Analysis
  De Francesco P et al. · Dentistry Journal · 2026
  Meta-analysisHumansWith zinc (as polaprezinc / zinc-L-carnosine)
• Efficacy and Safety of Polaprezinc-Based Therapy versus the Standard Triple Therapy for Helicobacter pylori Eradication: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
  Mahmoud A et al. · Nutrients · 2022
  Meta-analysisHumansWith zinc (as polaprezinc / zinc-L-carnosine) added to triple therapy
• Efficacy and safety of polaprezinc in the treatment of gastric ulcer: A multicenter, randomized, double-blind, double-dummy, positive-controlled clinical trial
  Shen W et al. · Medical Engineering & Physics · 2022
  Randomised controlled trialHumansWith zinc (as polaprezinc / zinc-L-carnosine)
• Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers
  Davison G et al. · American Journal of Clinical Nutrition · 2016
  Randomised controlled trialHumansWith zinc (as polaprezinc / zinc-L-carnosine); bovine colostrum in two arms
• Polaprezinc reduces the severity of radiation-induced mucositis in head and neck cancer patients
  Doi H et al. · Molecular and Clinical Oncology · 2015
  Controlled trialHumansTopicalWith zinc (as polaprezinc / zinc-L-carnosine) mouth rinse
• Effectiveness of polaprezinc for low-dose aspirin-induced small-bowel mucosal injuries as evaluated by capsule endoscopy: a pilot randomized controlled study
  Watari I et al. · BMC Gastroenterology · 2013
  Randomised controlled trialHumansWith zinc (as polaprezinc / zinc-L-carnosine)
• Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes
  Mahmood A et al. · Gut · 2007
  Laboratory studyOther animalsHumansWith zinc (as zinc carnosine)
• Applicability of zinc complex of L-carnosine for medical use
  Matsukura T et al. · Biochemistry (Moscow) · 2000
  ReviewHumansWith zinc (as polaprezinc)
• Intestinal absorption of the intact peptide carnosine in man, and comparison with intestinal permeability to lactulose
  Gardner ML et al. · Journal of Physiology · 1991
  Laboratory studyHumans
• Carnosinase activity of human gastrointestinal mucosa
  Sadikali F et al. · Gut · 1975
  Laboratory studyHumansOther animals