Role of histidine-related compounds as intracellular proton buffering constituents in vertebrate muscle
ReviewOther animals
- Design
- Review
- What was measured
- Review of intracellular proton buffering by histidine-related compounds (protein histidine, free histidine, carnosine, anserine, balenine) across vertebrate muscle.
What the authors reported
Histidine dipeptides such as carnosine and anserine, together with free histidine in some fish, are major non-bicarbonate buffers in muscle, and buffering capacity differs markedly between muscle types and species. Capacity is typically high in fast-twitch glycolytic muscles of animals adapted for anaerobic performance. The author reports a high correlation between buffering capacity, muscle concentration of these compounds and percentage of fast-twitch fibres, and takes this as support for proton buffering being their main physiological function.
Limits of this study
Review. Full text not read.
Source
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.