N alpha-acetylcarnosine is a prodrug of L-carnosine in ophthalmic application as antioxidant
Laboratory studyOther animalsTopicalWith N-acetylcarnosine (carnosine prodrug)
This study tested carnosine together with N-acetylcarnosine (carnosine prodrug). Its results cannot be assigned to carnosine alone. More combination studies.
- Design
- Laboratory study
- Dose used in the study
- 1 percent N-acetylcarnosine or 1 percent carnosine to the rabbit eye
- What was measured
- Imidazole content of rabbit aqueous humour by HPLC, TLC and ion-exchange chromatography after topical N-acetylcarnosine, carnosine or placebo, given by instillation, subconjunctival injection or ultrasound phoresis.
What the authors reported
Topical carnosine did not accumulate in the aqueous humour above placebo levels over 30 minutes. N-acetylcarnosine was hydrolysed dose-dependently during passage from cornea to aqueous humour, releasing carnosine within 15 to 30 minutes, and 1 percent N-acetylcarnosine was well tolerated. The authors propose N-acetylcarnosine as a carnosinase-resistant prodrug that delivers carnosine to the anterior eye at concentrations of 5 to 15 mmol/L.
Limits of this study
Rabbit pharmacokinetics; author affiliated with the developer of the product. An erratum was published in 1997. Abstract only.
Source
PubMed 8894306 · doi:10.1016/0009-8981(96)06356-5
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.