Possible Role of L-Carnosine in the Regulation of Blood Glucose through Controlling Autonomic Nerves
Controlled trialOther animals
- Design
- Controlled trial
- Dose used in the study
- 0.1%, 0.01% or 0.001% L-carnosine in the diet; intraperitoneal and intracerebroventricular injections in other experiments
- What was measured
- Hyperglycaemia induced by intracerebroventricular 2-deoxy-D-glucose in rats; effects of L-histidine, diphenhydramine and alpha-fluoromethylhistidine; plasma carnosine and carnosinase activity (daily changes, streptozotocin diabetes, running-wheel exercise); feeding response to 2-deoxy-D-glucose.
What the authors reported
Dietary carnosine at 0.01% or 0.001%, but not at the larger 0.1%, suppressed the induced hyperglycaemia. Intracerebroventricular but not intraperitoneal histidine suppressed it, and diphenhydramine and alpha-fluoromethylhistidine reduced it. Plasma carnosine was significantly lower in streptozotocin-diabetic rats and showed daily changes, and wheel running tended to raise muscle carnosine synthase activity and plasma carnosine in the dark period. The authors earlier reported that thioperamide abolished the carnosine effect and that carnosine inhibited sympathetic and facilitated parasympathetic nerves, and suggest carnosine released from exercising muscle may lower blood glucose through autonomic nerves.
Limits of this study
Animal numbers and duration not stated in abstract. Rodents lack serum carnosinase, so oral results do not carry over to people. Full text not read.
Source
PubMed 14610252 · doi:10.1177/153537020322801007
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.