A CTG Polymorphism in the CNDP1 Gene Determines the Secretion of Serum Carnosinase in Cos-7-Transfected Cells
Laboratory studyHumansOther animals
- Design
- Laboratory study
- What was measured
- CNDP1 exon 2 CTG repeat alleles (4 to 8 leucines) in diabetic patients, and carnosinase secretion from Cos-7 cells transfected with each variant.
What the authors reported
Diabetic patients without nephropathy were more often homozygous for the 5-leucine allele. Cos-7 cells expressing the longer leucine variants secreted significantly more serum carnosinase than cells expressing the 5-leucine form. The authors propose this explains the low serum carnosinase activity seen in people with the protective genotype.
Limits of this study
Secretion data come from a transfected cell line, not human serum. Patient numbers not stated in abstract. Full text not read.
Source
PubMed 17601991 · doi:10.2337/db07-0128
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.