Carnosine prevents apoptosis of glomerular cells and podocyte loss in STZ diabetic rats
Laboratory studyOther animals
- Design
- Laboratory study
- Dose used in the study
- 1 g/kg body weight per day L-carnosine
- Duration
- 3 months
- What was measured
- Kidney carnosine content, podocyte number, apoptotic glomerular cells, Bax and cytochrome c, plus reactive oxygen species, AGEs and GlcNAc-modified proteins in streptozotocin-diabetic Wistar rats after 3 months.
What the authors reported
Hyperglycaemia lowered kidney carnosine, reduced podocyte number (-21% versus non-diabetic), raised apoptotic glomerular cells (32%) and raised Bax (175%) and cytochrome c (117%). Oral carnosine restored kidney carnosine, prevented podocyte loss (+23% versus diabetic), reduced glomerular apoptosis (-34%) and lowered Bax (-63%) and cytochrome c (-54%). Reactive oxygen species, AGEs and GlcNAc-modified proteins were raised in all diabetic animals, and the authors conclude the protection was independent of these biochemical abnormalities.
Limits of this study
Rat model. Rodents lack serum carnosinase, so oral results do not carry over to people. Sample size not stated in abstract. Full text not read.
Source
PubMed 21865735 · doi:10.1159/000331740
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.