Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes
Observational studyHumans
- Design
- Observational study
- Subjects
- 1,269 Caucasian patients with type 1 diabetes
- Duration
- 6-year follow-up
- What was measured
- D18S880 microsatellite and 21 SNPs across CNDP2-CNDP1 in 613 normoalbuminuric, 445 proteinuric and 211 end-stage renal disease patients; incident ESRD over 6 years.
What the authors reported
No significant association was found between CNDP1 or CNDP2 variants and diabetic nephropathy or end-stage renal disease in type 1 diabetes. A 6-year follow-up in which 135 patients progressed to ESRD supported the negative result.
Limits of this study
Genetic association study in type 1 diabetes only; results do not address type 2 diabetes, where CNDP1 associations were originally reported. Abstract only.
Source
Entry checked against OpenAlex record (abstract) on 2026-10-17. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.