The influence of a single nucleotide polymorphism within CNDP1 on susceptibility to diabetic nephropathy in Japanese women with type 2 diabetes
Observational studyHumans
- Design
- Observational study
- Subjects
- 2,740 Japanese subjects (1,205 with diabetic nephropathy, 1,535 normoalbuminuric controls)
- What was measured
- The D18S880 leucine repeat marker and 29 SNPs across the CNDP1/CNDP2 region, tested for association with diabetic nephropathy (overt nephropathy or end-stage renal disease).
What the authors reported
No association was found between D18S880 or any of the 29 SNPs and diabetic nephropathy in the overall sample. In sex-stratified analysis, rs12604675-A was nominally associated with diabetic nephropathy in women (p = 0.005, odds ratio 1.76, 95% CI 1.19 to 2.61) and with overt proteinuria (p = 0.002, odds ratio 2.18, 95% CI 1.32 to 3.60) but not with end-stage renal disease.
Limits of this study
Sex-specific association was nominal and would not survive strict correction; replication not reported in abstract. Full text not read. Case-control genetic association design.
Source
PubMed 23342076 · doi:10.1371/journal.pone.0054064
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.