Profiling histidine dipeptides in plasma and urine after ingesting beef, chicken or chicken broth in humans
Open-label, no control groupHumans
- Design
- Open-label, no control group
- Subjects
- 4 healthy women
- Dose used in the study
- 450 mg pure carnosine, 150 g beef, 150 g chicken or broth from 150 g chicken, one dose per phase
- Duration
- single doses with more than 2 weeks washout between four phases; sampling to 5 hours (plasma) and 7 hours (urine)
- What was measured
- Plasma and urinary carnosine and anserine by LC-ESI-MS/MS after each test meal, and in vitro stability of the dipeptides in human serum.
What the authors reported
Carnosine was undetectable in plasma after pure carnosine, beef, chicken or chicken broth. Plasma anserine rose significantly after chicken and chicken broth. Urinary carnosine and anserine rose 13- to 14-fold after beef, and 14.8- and 243-fold respectively after chicken broth. The authors conclude dietary histidine dipeptides are rapidly hydrolysed by plasma carnosinase and excreted, and may act as carbonyl-sequestering agents.
Limits of this study
Four participants, single doses, no control arm. Published online 2009, in print 2010. Abstract only.
Source
PubMed 19381778 · doi:10.1007/s00726-009-0291-2
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.