The effect of carnosine pretreatment on oxidative stress and hepatotoxicity in binge ethanol administered rats
Laboratory studyOther animals
- Design
- Laboratory study
- Dose used in the study
- 2 g/L in drinking water
- Duration
- 4 weeks of carnosine in drinking water before ethanol
- What was measured
- Plasma ALT and AST, liver triglyceride, malondialdehyde, diene conjugates, glutathione, vitamins E and C and antioxidant enzymes after three oral ethanol doses of 5 g/kg given 12 hours apart.
What the authors reported
Binge ethanol raised plasma transaminases and liver triglyceride and lipid peroxides and lowered glutathione, vitamins E and C and some enzyme activities. Carnosine pretreatment appeared to prevent the rises in ALT, AST, malondialdehyde and diene conjugates and raised liver glutathione. It did not change triglyceride, vitamins, antioxidant enzyme activities or the fatty change (steatosis) in the liver.
Limits of this study
Rat model; group sizes not given in abstract. Rodents lack serum carnosinase, so oral results do not carry over to people. Full text not read.
Source
PubMed 20064906 · doi:10.1177/0960327109359460
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.