Effect of Anserine/Carnosine Supplementation on Verbal Episodic Memory in Elderly People
Randomised controlled trialHumansWith anserine (3:1 anserine to carnosine formula)
This study tested carnosine together with anserine (3:1 anserine to carnosine formula). Its results cannot be assigned to carnosine alone. More combination studies.
- Design
- Randomised controlled trial
- Subjects
- 39 healthy volunteers aged 60 to 78 completed follow-up (double-blind, 1:1 randomisation); a second randomised trial is also reported
- Dose used in the study
- 1.0 g per day of a 3:1 anserine/carnosine formula
- Duration
- 3 months
- What was measured
- Wechsler Memory Scale-Logical Memory (delayed verbal recall), blood cytokines (CCL-2, IL-8), and brain blood flow by arterial spin labelling MRI.
What the authors reported
Delayed verbal recall was preserved in the supplement group compared with placebo (p = 0.0128). Secretion of inflammatory cytokines CCL-2 and IL-8 decreased. Age-related decline in blood flow in the posterior cingulate cortex was suppressed compared with placebo (p = 0.0248). A second randomised trial reported in the same paper found similar preservation of delayed recall (p = 0.0202).
Limits of this study
Small trials; group sizes and the second trial's size are not given in the abstract. Mostly anserine (3:1 anserine to carnosine), not carnosine alone. Three months. The authors say further study is needed. Full text not read.
Source
PubMed 26682691 · doi:10.3233/JAD-150767
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.