Effects of alpha-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats
Controlled trialOther animalsWith alpha-lipoic acid (in two of three treatment groups)
This study tested carnosine together with alpha-lipoic acid (in two of three treatment groups). Its results cannot be assigned to carnosine alone. More combination studies.
- Design
- Controlled trial
- Dose used in the study
- 0.5% L-carnosine, or 0.25% L-carnosine plus 0.25% alpha-lipoic acid, or 0.5% alpha-lipoic acid in the diet
- Duration
- 6 weeks
- What was measured
- Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde in serum, skin and liver; serum triglycerides, total, HDL and LDL cholesterol.
What the authors reported
Skin and liver SOD activity was higher in the alpha-lipoic acid and carnosine groups than in controls (P < 0.05); serum SOD was higher only in the carnosine group, and liver GSH-Px only in the carnosine group. Serum and skin malondialdehyde were lower in the alpha-lipoic acid and carnosine groups. Serum triglycerides and total cholesterol were lower in the alpha-lipoic acid and combination groups than in controls and the carnosine group. HDL cholesterol was higher in the carnosine group, and LDL cholesterol was lower in the combination and carnosine groups than in controls.
Limits of this study
Group sizes not stated in abstract. Rodents lack serum carnosinase, so oral results do not carry over to people. Full text not read.
Source
PubMed 22125679 · doi:10.4162/nrp.2011.5.5.421
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.