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Dietary carnitine and carnosine increase body lean in healthy cats in a preliminary study

Panickar KS, DeBey MC, Jewell DE. Biology (Basel), 2021; 10(4):299.

Controlled trialCatsWith L-carnitine in some arms (carnosine-alone arm also included)

This study tested carnosine together with L-carnitine in some arms (carnosine-alone arm also included). Its results cannot be assigned to carnosine alone. More combination studies.

Design
Controlled trial
Subjects
45 healthy adult cats aged 6.2 to 13.9 years, in four diet groups (group sizes not stated)
Dose used in the study
control food; control plus 300 mg/kg L-carnitine; control plus 1000 mg/kg carnosine; control plus both
Duration
169 days
What was measured
Lean and fat body mass, circulating glucose and triglycerides, serum metabolomics and cytokine concentrations.

What the authors reported

The authors report that carnitine alone and carnosine alone increased lean body mass compared with the control food or the combination food (final lean mass: control 3591 g, carnitine 3805 g, carnosine 3819 g, combination 3542 g). Carnitine alone lowered circulating cytokines. The combination raised glucose, pyruvate, succinate, triglycerides and 8 of 10 measured cytokines. The authors describe the study as preliminary.

Limits of this study

Described by the authors as preliminary; group sizes not stated; industry-affiliated authors; the combination arm showed changes the authors did not expect from the single ingredients.

Source

doi:10.3390/biology10040299

Entry checked against full text (journal site, MDPI) on 2026-10-11. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.