Insulin-like growth factor I plays a role in gastric wound healing: evidence using a zinc derivative, polaprezinc, and an in vitro rabbit wound repair model
Laboratory studyOther animalsWith zinc (as polaprezinc)
This study tested carnosine together with zinc (as polaprezinc). Its results cannot be assigned to carnosine alone. More combination studies.
- Design
- Laboratory study
- Duration
- 48 hours of wound closure
- What was measured
- Closure of a circular artificial wound in rabbit gastric epithelial monolayers treated with polaprezinc, IGF-I, fibroblast-conditioned medium or anti-IGF-I-neutralised medium; IGF-I, HGF and TGF-alpha mRNA in fibroblasts with and without polaprezinc; epithelial cell proliferation by BrdU staining.
What the authors reported
IGF-I and fibroblast-conditioned medium accelerated epithelial restoration, including migration and proliferation. Polaprezinc and neutralised conditioned medium did not accelerate repair. IGF-I mRNA expression in fibroblasts rose after polaprezinc treatment. The authors conclude polaprezinc induced IGF-I production from mesenchymal cells, stimulating epithelial restoration through a paracrine pathway.
Limits of this study
In vitro rabbit cell model; no whole-animal or human data. Full text not read.
Source
PubMed 9845403 · doi:10.1046/j.1365-2036.1998.00408.x
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.