Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes
Observational studyHumans
- Design
- Observational study
- Subjects
- 4,888 unrelated patients with type 2 diabetes (Scania Diabetes Registry, Sweden)
- What was measured
- Nine single nucleotide polymorphisms and the D18S880 trinucleotide (leucine) repeat in CNDP1 and CNDP2; diabetic nephropathy (micro- or macroalbuminuria) and estimated GFR.
What the authors reported
rs2346061 in CNDP1 was associated with higher risk of diabetic nephropathy (p = 5.07 x 10^-4) and rs7577 in CNDP2 with nephropathy (p = 0.021) and with estimated GFR (beta = -0.037, p = 0.014), most evident in women. A C-C-G haplotype of these SNPs carried about threefold higher odds of nephropathy (OR 2.98, 95 percent CI 2.43 to 3.67, p less than 0.0001). The authors concluded that common CNDP1 and CNDP2 variants contribute to kidney disease susceptibility in type 2 diabetes.
Limits of this study
Case-control genetic association in one Swedish registry; no carnosine levels measured.
Source
PubMed 21573905 · doi:10.1007/s00125-011-2178-5
Entry checked against publisher PDF (abstract) on 2026-10-17. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.