Association Between CNDP1 Genotype and Diabetic Nephropathy Is Sex Specific
Observational studyHumans
- Design
- Observational study
- Subjects
- three cohorts of type 2 diabetes patients with nephropathy (114, 90 and 66), 93 type 2 diabetes controls with more than 15 years of diabetes and no nephropathy, 472 population controls, and 562 type 2 diabetes patients without nephropathy
- What was measured
- CNDP1 (CTG)n leucine-repeat genotype by sex, with odds of diabetic nephropathy.
What the authors reported
The 5-5 homozygous CNDP1 genotype occurred in 28, 36 and 41% of the three nephropathy groups versus 43% of diabetic controls and 42% of population controls, and was significantly less frequent in women in all three patient groups than in diabetic controls. The estimated genotype odds ratio was 0.5 (0.30 to 0.68) in women and 1.2 (0.77 to 1.69) in men. The 562 patients with type 2 diabetes without nephropathy did not differ from the general population (P = 0.23), which the authors took to mean the association is independent of type 2 diabetes susceptibility.
Limits of this study
Genetic association study in European cohorts; carnosine levels were not measured. Full text not read.
Source
PubMed 20332346 · doi:10.2337/db09-1377
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.