Low plasma carnosinase activity promotes carnosinemia after carnosine ingestion in humans
Open-label, no control groupHumans
- Design
- Open-label, no control group
- Subjects
- 25 healthy adults
- Dose used in the study
- 60 mg/kg body weight carnosine, single oral dose
- What was measured
- Plasma and urinary carnosine, plasma carnosinase (CN1) activity, after a single oral dose.
What the authors reported
Eight of 25 subjects (responders) showed a measurable rise in plasma carnosine up to 1 hour after ingestion. Non-responders had about 2-fold higher plasma carnosinase protein content and about 1.5-fold higher activity. Urinary carnosine recovery was 2.6-fold higher in responders and depended negatively on both carnosinase activity and protein content. The authors conclude low plasma carnosinase activity promotes circulating carnosine after an oral dose, and say the data may clarify the link between CNDP1 genotype, carnosinase and diabetic nephropathy.
Limits of this study
Single acute dose in healthy volunteers; no clinical outcomes. Full text not read.
Source
PubMed 22496410 · doi:10.1152/ajprenal.00084.2012
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.