The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans
Observational studyHumans
- Design
- Observational study
- Subjects
- 1025 African-American cases with type 2 diabetes-associated end-stage renal disease and 1064 non-diabetic non-nephropathy controls
- What was measured
- 64 variants identified by sequencing CNDP1 and CNDP2; 12 SNPs and the D18S880 leucine repeat genotyped in cases and controls.
What the authors reported
Two SNPs (rs6566810 and rs4892247) and several two- and three-marker haplotypes in CNDP1 and CNDP2 were associated with diabetic end-stage renal disease (global empirical P from 0.0275 down to 1.5E-05). Risk haplotypes were most strongly associated in people who were not 5L-5L homozygous. The authors suggest the protection from 5L-5L homozygosity seen in Europeans may be masked in African-Americans by additional risk haplotypes.
Limits of this study
Case-control association study; no measurement of carnosine or enzyme activity. Abstract only.
Source
PubMed 19373489 · doi:10.1007/s00439-009-0667-0
Entry checked against PubMed abstract (E-utilities) on 2026-10-19. The dose shown is the dose the researchers used. It is not a recommendation. How to read this page.